The PDGF Receptor Beta Rabbit Monoclonal Antibody (CAB19531) is a powerful tool for researchers studying the PDGF receptor beta, a key player in cell growth, proliferation, and differentiation. This antibody, generated in rabbits, is highly specific to human samples and has been rigorously validated for use in Western blot applications.The PDGF receptor beta is a vital component in several cellular processes, including wound healing, tissue repair, and angiogenesis. Dysregulation of this receptor has been implicated in various diseases, making it a prime target for therapeutic interventions.
By using the PDGF Receptor Beta Rabbit Monoclonal Antibody, researchers can accurately detect and analyze the expression of this receptor in different cell types, shedding light on its role in diseases such as cancer, fibrosis, and cardiovascular disorders.With its high specificity and sensitivity, the PDGF Receptor Beta Rabbit Monoclonal Antibody is an essential tool for advancing our understanding of the PDGF receptor beta and its implications in various pathological conditions. Its versatility and reliability make it ideal for studies in cell biology, oncology, and drug development.
Product Name:
PDGFRB Rabbit Monoclonal Antibody
SKU:
CAB19531
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1000-1106 of human PDGFRB (P09619).
Cell membrane, Cytoplasmic vesicle, Lysosome lumen, Single-pass type I membrane protein.
Calculated MW:
124kDa
Observed MW:
170kDa
The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia.
Purification Method:
Affinity purification
Gene ID:
5159
Clone Number:
ARC0009
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDGFRB Rabbit mAb (CAB19531) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
