UniProt Protein Function: | Involved in the control of the switch from cell motility to adhesion via regulation of cellular levels of cyclic-di-GMP (c-di-GMP) (PubMed:18765794). Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two c-di-GMP control modules, in which c-di-GMP controlled by the DgcE/PdeH pair (module I) regulates the activity of the DgcM/PdeR pair (module II), which in turn regulates activity of the transcription factor MlrA and expression of the master biofilm regulator csgD (PubMed:23708798). Effect on flagella is controlled via the c-di-GMP-binding flagellar brake protein YcgR (PubMed:18765794). |
UniProt Protein Details: | |
NCBI Summary: | Overexpressed Salmonella typhimurium YhjH (STM3611) enhances motitility, counteracts cellulose biosynthesis and the rdar phenotype, and mediates cyclic-di-GMP degradation. [More information is available at EcoGene: EG12252]. YhjH is a c-di-GMP phosphodiesterase involved in regulation of the switch from flagellar motility to sessile behavior and curli expression at the end of exponential growth . [More information is available at EcoCyc: EG12252]. |
UniProt Code: | P37646 |
NCBI GenInfo Identifier: | 90111605 |
NCBI Gene ID: | 948042 |
NCBI Accession: | NP_417982.2 |
UniProt Secondary Accession: | P37646,Q2M7I7 |
UniProt Related Accession: | P37646 |
Molecular Weight: | 29,601 Da |
NCBI Full Name: | cyclic-di-GMP phosphodiesterase, FlhDC-regulated |
NCBI Synonym Full Names: | |
NCBI Official Symbol: | yhjHÂ Â |
NCBI Official Synonym Symbols: | ECK3510; JW3493Â Â |
NCBI Protein Information: | cyclic-di-GMP phosphodiesterase, FlhDC-regulated |
UniProt Protein Name: | Cyclic di-GMP phosphodiesterase PdeH |
UniProt Synonym Protein Names: | |
Protein Family: | |
UniProt Gene Name: | pdeHÂ Â |
UniProt Entry Name: | |