The PDEH Polyclonal Antibody (PACO63583) is a valuable tool for researchers studying phosphodiesterase H (PDEH), an enzyme involved in intracellular signaling pathways related to cell growth and differentiation. This antibody, produced in rabbits, is highly specific to human PDEH and has been validated for use in Western blot applications.PDEH is known to play a role in regulating cyclic nucleotide levels, which in turn affects cellular processes such as gene expression and protein synthesis. Dysregulation of PDEH activity has been implicated in various diseases, including cancer, cardiovascular disorders, and neurological conditions.
By targeting PDEH with this antibody, researchers can gain insights into its function and potential therapeutic implications.The PDEH Polyclonal Antibody is a reliable tool for detecting and quantifying PDEH protein levels in different cell types, making it suitable for experiments in cell biology, biochemistry, and drug development. Its specificity and sensitivity make it an essential component of any research aiming to understand the intricate mechanisms of PDEH signaling pathways and their implications in disease pathogenesis.
Antibody Name:
pdeH Antibody (PACO63583)
Antibody SKU:
PACO63583
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:2000-1:10000
Species Reactivity:
Escherichia coli
Immunogen:
Recombinant Escherichia coli Cyclic di-GMP phosphodiesterase PdeH protein (1-255AA)
Western Blot. Positive WB detected in Recombinant protein. All lanes: pdeH antibody at 1:2500. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 35 kDa. Observed band size: 34 kDa.
Background:
Involved in the control of the switch from cell motility to adhesion via regulation of cellular levels of cyclic-di-GMP (c-di-GMP). Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two c-di-GMP control modules, in which c-di-GMP controlled by the DgcEPdeH pair (module I) regulates the activity of the DgcMPdeR pair (module II), which in turn regulates activity of the transcription factor MlrA and expression of the master biofilm regulator csgD. Effect on flagella is controlled via the c-di-GMP-binding flagellar brake protein YcgR.
Synonyms:
Cyclic di-GMP phosphodiesterase PdeH, pdeH, yhjH
UniProt Protein Function:
Involved in the control of the switch from cell motility to adhesion via regulation of cellular levels of cyclic-di-GMP (c-di-GMP) (PubMed:18765794). Part of a signaling cascade that regulates curli biosynthesis. The cascade is composed of two c-di-GMP control modules, in which c-di-GMP controlled by the DgcE/PdeH pair (module I) regulates the activity of the DgcM/PdeR pair (module II), which in turn regulates activity of the transcription factor MlrA and expression of the master biofilm regulator csgD (PubMed:23708798). Effect on flagella is controlled via the c-di-GMP-binding flagellar brake protein YcgR (PubMed:18765794).
UniProt Protein Details:
NCBI Summary:
Overexpressed Salmonella typhimurium YhjH (STM3611) enhances motitility, counteracts cellulose biosynthesis and the rdar phenotype, and mediates cyclic-di-GMP degradation. [More information is available at EcoGene: EG12252]. YhjH is a c-di-GMP phosphodiesterase involved in regulation of the switch from flagellar motility to sessile behavior and curli expression at the end of exponential growth . [More information is available at EcoCyc: EG12252].
