The PDE9A Monoclonal Antibody (PAC013758) is a powerful tool for researchers studying PDE9A, a phosphodiesterase enzyme involved in regulating cellular signaling pathways. This antibody, produced through a monoclonal process, exhibits high specificity and sensitivity for detecting PDE9A in human samples, making it a reliable option for a variety of experimental techniques including Western blotting.PDE9A is known for its role in modulating cyclic nucleotide signaling, impacting processes such as cell growth, metabolism, and neuronal function.
Dysregulation of PDE9A has been linked to various diseases, including neurological disorders and cardiovascular conditions, making it a promising target for therapeutic interventions. By using the PDE9A Monoclonal Antibody, researchers can explore the function and localization of PDE9A in different cell types and tissues, advancing our understanding of its potential implications in health and disease.
Antibody Name:
PDE9A Antibody (PACO13758)
Antibody SKU:
PACO13758
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Human CD99
Form:
Liquid
Storage Buffer:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
PDE9A: Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily. 16 isoforms of the human protein are produced by alternative splicing.Protein type: Phosphodiesterase; Nucleotide Metabolism - purine; EC 3.1.4.35Chromosomal Location of Human Ortholog: 21q22.3Cellular Component: Golgi apparatus; endoplasmic reticulum; perinuclear region of cytoplasm; perikaryon; cytosolMolecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; protein binding; metal ion binding; 3',5'-cyclic-nucleotide phosphodiesterase activityBiological Process: cGMP-mediated signaling; metabolic process; blood coagulation; signal transduction
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
