The PDE6H Polyclonal Antibody (PAC035442) is a key tool for researchers studying PDE6H, a protein involved in vision and the visual transduction cascade. This antibody, produced in rabbits, exhibits high specificity towards human samples and has been validated for use in Western blot applications. By binding to the PDE6H protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential resource for studies in ophthalmology and vision science.PDE6H, also known as rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit eta, plays a crucial role in the phototransduction process in rod cells of the retina. Dysregulation of PDE6H function has been associated with various retinal diseases, including retinitis pigmentosa.
By investigating the function and expression of PDE6H, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially develop novel therapeutic strategies for treating vision disorders.Overall, the PDE6H Polyclonal Antibody is a valuable tool for researchers interested in elucidating the role of PDE6H in vision-related processes and exploring its potential as a target for therapeutic intervention in retinal diseases. Its high specificity and reliability make it an indispensable asset for advancing our understanding of vision biology and developing innovative treatment approaches.
Antibody Name:
PDE6H Antibody (PACO35442)
Antibody SKU:
PACO35442
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit γ protein (1-83AA)
IHC image of PACO35442 diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.
UniProt Protein Details:
NCBI Summary:
This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A). [provided by RefSeq, Mar 2010]
