The PDE6G Polyclonal Antibody (CAB17516) is specifically designed for research involving PDE6G, a protein that plays a key role in the visual transduction pathway. This antibody, raised in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the PDE6G protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal tool for studies in vision research and retinal disorders.PDE6G is a crucial component of the phototransduction cascade in rod cells, where it serves to regulate cGMP levels and facilitate the visual response to light.
Dysregulation of PDE6G has been associated with various retinal diseases, including retinitis pigmentosa and night blindness. As such, further research into the function and regulation of PDE6G is essential for advancing our understanding of these conditions and potentially developing targeted treatments.This polyclonal antibody offers researchers a reliable tool for investigating the role of PDE6G in vision and retinal health, providing valuable insights into the mechanisms underlying visual impairment and offering potential therapeutic avenues for retinal disorders.
Product Name:
PDE6G Rabbit Polyclonal Antibody
SKU:
CAB17516
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-87 of human PDE6G (NP_002593.1).
This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5148
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDE6G Rabbit pAb (CAB17516) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
