The PDE6D Polyclonal Antibody (CAB14762) is a valuable tool for researchers studying the role of the PDE6D protein in cellular signaling and function. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.PDE6D is a key enzyme in the visual cycle, playing a crucial role in the regulation of phototransduction in the retina. Dysfunction of PDE6D has been linked to various retinal degenerative diseases, making it a potential target for therapeutic interventions aimed at preserving vision.
By utilizing the PDE6D Polyclonal Antibody, researchers can investigate the expression levels and localization of PDE6D in different cell types and tissues, providing valuable insights into its function and potential implications in disease pathology. This antibody is a valuable tool for studies in vision biology, ophthalmology, and molecular medicine.
Product Name:
PDE6D Rabbit Polyclonal Antibody
SKU:
CAB14762
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PDE6D (NP_002592.1).
This gene encodes the delta subunit of rod-specific photoreceptor phosphodiesterase (PDE), a key enzyme in the phototransduction cascade. A similar protein in cow functions in solubilizing membrane-bound PDE. In addition to its role in the PDE complex, the encoded protein is thought to bind to prenyl groups of proteins to target them to subcellular organelles called cilia. Mutations in this gene are associated with Joubert syndrome-22. Alternative splicing results in multiple splice variants.
Purification Method:
Affinity purification
Gene ID:
5147
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDE6D Rabbit pAb (CAB14762) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
