PDE6B Rabbit Polyclonal Antibody (CAB6942)
- SKU:
- CAB6942
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | PDE6B Rabbit Polyclonal Antibody |
SKU: | CAB6942 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human PDE6B (NP_001138763.1). |
Sequence: | MSLS EEQA RSFL DQNP DFAR QYFG KKLS PENV AAAC EDGC PPDC DSLR DLCQ VEES TALL ELVQ DMQE SINM ERVV FKVL RRLC TLLQ ADRC SLFM YRQR NGVA ELAT RLFS VQPD SVLE DCLV PPDS EIVF PLDI GVVG HVAQ TKKM VNVE DVAE CPHF SSFA DELT DYKT KNML ATPI MNGK DVVA VI |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | rd1; PDEB; RP40; CSNB3; CSNBAD2; GMP-PDEbeta; PDE6B |
Positive Sample: | Mouse liver,Mouse pancreas,Mouse heart,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Lipid-anchor, Membrane. |
Calculated MW: | 98kDa |
Observed MW: | 98kDa |
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5158 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |