PDE6A Rabbit Polyclonal Antibody (CAB7915)
- SKU:
- CAB7915
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | PDE6A Rabbit Polyclonal Antibody |
SKU: | CAB7915 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 656-860 of human PDE6A (NP_000431.2). |
Sequence: | EHAI HMMD IAII ATDL ALYF KKRT MFQK IVDQ SKTY ESEQ EWTQ YMML EQTR KEIV MAMM MTAC DLSA ITKP WEVQ SQVA LLVA AEFW EQGD LERT VLQQ NPIP MMDR NKAD ELPK LQVG FIDF VCTF VYKE FSRF HEEI TPML DGIT NNRK EWKA LADE YDAK MKVQ EEKK QKQQ SAKS AAAG NQPG GNPS PGGA TTSK SCCI Q |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | PDEA; RP43; CGPR-A; PDE6A |
Positive Sample: | BT-474,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasmic side, Lipid-anchor. |
Calculated MW: | 100kDa |
Observed MW: | 120kDa |
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
Purification Method: | Affinity purification |
Gene ID: | 5145 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |