The PDE4D Polyclonal Antibody (CAB1659) is a valuable tool for researchers studying phosphodiesterase 4D (PDE4D), an enzyme involved in the regulation of intracellular levels of cyclic AMP (cAMP), a key signaling molecule. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By specifically binding to the PDE4D protein, this antibody allows for the detection and analysis of PDE4D expression in various cell types.PDE4D plays a crucial role in a variety of cellular processes, including cell growth, differentiation, and inflammation, making it an important target for research in areas such as cancer, cardiovascular disease, and neurodegenerative disorders.
By studying the expression and activity of PDE4D, researchers can gain insights into the underlying mechanisms of these diseases and potentially identify new therapeutic targets.Overall, the PDE4D Polyclonal Antibody (CAB1659) is a valuable tool for researchers looking to investigate the role of PDE4D in cellular signaling pathways and disease states, ultimately contributing to the advancement of knowledge in the field of molecular biology and drug discovery.
Product Name:
PDE4D Rabbit Polyclonal Antibody
SKU:
CAB1659
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 249-518 of human PDE4D (NP_001184152.1).
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
Purification Method:
Affinity purification
Gene ID:
5144
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from rat brain, using PDE4D Rabbit pAb (CAB1659) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
