The PDE4D Polyclonal Antibody (CAB13937) is a crucial tool for research involving PDE4D, a key enzyme involved in intracellular signaling pathways. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the PDE4D protein, researchers can detect and analyze its expression in various cell types, facilitating studies in signal transduction, cell proliferation, and drug development.PDE4D is a member of the phosphodiesterase family that plays a critical role in the regulation of cyclic AMP levels, influencing various cellular functions such as inflammation, neuroplasticity, and smooth muscle relaxation.
Dysregulation of PDE4D has been implicated in diseases like cancer, neurodegenerative disorders, and inflammatory conditions, making it a promising therapeutic target. By studying PDE4D activity, researchers can gain insights into disease mechanisms and develop novel treatments that target this enzyme.
Product Name:
PDE4D Rabbit Polyclonal Antibody
SKU:
CAB13937
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 249-518 of human PDE4D (NP_001184152.1).
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
Purification Method:
Affinity purification
Gene ID:
5144
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PDE4D antibody (CAB13937) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
