The PDE4B Polyclonal Antibody is designed for research involving PDE4B, a crucial enzyme involved in the regulation of various cellular processes, including inflammation and immune responses. The antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically binds to the PDE4B protein, allowing for accurate detection and analysis in a wide range of cell types.PDE4B is a key player in intracellular signaling pathways that control inflammation and immune cell function. Dysregulation of PDE4B has been linked to several inflammatory diseases, making it a potential therapeutic target for conditions such as asthma, COPD, and rheumatoid arthritis.
Research into the role of PDE4B in immune regulation is essential for the development of targeted therapies that can modulate immune responses effectively.With its high specificity and sensitivity, the PDE4B Polyclonal Antibody is an essential tool for scientists studying the intricate mechanisms of immune regulation and inflammation. Its versatility in various research applications makes it an invaluable asset in advancing our understanding of PDE4B-related diseases and developing novel treatment strategies.
Product Name:
PDE4B Polyclonal Antibody
SKU:
CAB23257
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 636-736 of human PDE4B (NP_002591.2).
centrosome, cytosol, dendritic spine, excitatory synapse, gamma-tubulin complex, nucleus, perinuclear region of cytoplasm, postsynaptic density, synaptic vesicle, Z disc
Calculated MW:
83kDa
Observed MW:
90kDa
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
5142
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Mouse lung, using PDE4B Rabbit pAb (CAB23257) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
