The PDE4B/PDE4C/PDE4D Antibody (PACO07067) is a valuable tool for researchers studying phosphodiesterases, a group of enzymes involved in intracellular signaling pathways. This polyclonal antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. It targets PDE4B, PDE4C, and PDE4D proteins, allowing for precise detection and analysis in various cell types.Phosphodiesterases are key regulators of cyclic nucleotide levels, playing essential roles in cellular processes such as cell growth, differentiation, and inflammation. The PDE4B/PDE4C/PDE4D Antibody is instrumental in understanding the functions of these specific phosphodiesterases and their implications in signaling pathways associated with diseases like cancer, cardiovascular conditions, and neurological disorders.
By utilizing this antibody, researchers can gain insights into the role of PDE4B, PDE4C, and PDE4D in cell signaling and disease development, ultimately advancing our understanding of potential therapeutic targets for various pathologies. With its high sensitivity and specificity, the PDE4B/PDE4C/PDE4D Antibody is a valuable tool in the fields of pharmacology, cell biology, and drug discovery.
Antibody Name:
PDE4B/PDE4C/PDE4D Antibody (PACO07067)
Antibody SKU:
PACO07067
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
ELISA:1:10000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from human PDE4B/C/D around the non-phosphorylation site of S133/119/190.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of various cells using PDE4B/C/D Polyclonal Antibody.
Western Blot analysis of K562 cells using PDE4B/C/D Polyclonal Antibody.
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
NCBI Summary:
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
