PDE3A Rabbit Polyclonal Antibody (CAB17919)
- SKU:
- CAB17919
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | PDE3A Rabbit Polyclonal Antibody |
SKU: | CAB17919 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 380-660 of human PDE3A (NP_000912.3). |
Sequence: | LLST QLTF QAIH KPRV NPVT SLSE NYTC SDSE ESSE KDKL AIPK RLRR SLPP GLLR RVSS TWTT TTSA TGLP TLEP APVR RDRS TSIK LQEA PSSS PDSW NNPV MMTL TKSR SFTS SYAI SAAN HVKA KKQS RPGA LAKI SPLS SPCS SPLQ GTPA SSLV SKIS AVQF PESA DTTA KQSL GSHR ALTY TQSA PDLS PQIL TPPV ICSS CGRP YSQG NPAD EPLE RSGV ATRT PSRT DDTA QVTS DYET NNNS DSSD IVQN EDET ECLR EPLR KASA CSTY A |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:100 |
Synonyms: | HTNB; CGI-PDE; CGI-PDE A; CGI-PDE-A; PDE3A |
Positive Sample: | HepG2,mouse lung,mouse heart,mouse brain |
Cellular Localization: | cytosol |
Calculated MW: | 125kDa |
Observed MW: | 125kDa |
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5139 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |