The PDE1C Polyclonal Antibody (CAB15078) is specifically designed for research involving PDE1C, a key enzyme that regulates intracellular levels of cyclic nucleotides, specifically cAMP and cGMP. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in Western blot and immunohistochemistry applications.PDE1C plays a crucial role in modulating cellular signaling pathways involved in various physiological processes, including smooth muscle contraction, cardiac function, and neuronal signaling. Dysregulation of PDE1C has been implicated in a number of diseases, making it a promising target for drug development and therapeutic interventions.
By binding to the PDE1C protein, this polyclonal antibody enables accurate detection and analysis of PDE1C expression in a variety of cell types, making it an invaluable tool for researchers in the fields of cardiovascular biology, neuroscience, and drug discovery. Understanding the role of PDE1C in cellular signaling pathways is essential for unraveling its potential therapeutic implications in diseases such as heart failure, pulmonary hypertension, and neurological disorders.
Product Name:
PDE1C Rabbit Polyclonal Antibody
SKU:
CAB15078
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 435-634 of human PDE1C (NP_001177985.1).
This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta.
Purification Method:
Affinity purification
Gene ID:
5137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDE1C Rabbit pAb (CAB15078) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
