The PDE1B Polyclonal Antibody (CAB2102) is a key tool for researchers studying PDE1B, an enzyme involved in cell signaling and regulation of intracellular levels of cyclic nucleotides. This antibody, produced in rabbits, is highly specific for detecting PDE1B in human samples and has been validated for use in Western blot applications.PDE1B plays a vital role in various physiological processes, including regulation of cardiovascular function, smooth muscle contraction, and neuronal signaling. Dysregulation of PDE1B has been implicated in diseases such as heart failure, hypertension, and neurological disorders.
The ability to detect and quantify PDE1B levels using this antibody is essential for understanding its function and for developing targeted therapies for related conditions.By utilizing the PDE1B Polyclonal Antibody, researchers can further investigate the mechanisms underlying PDE1B activity and its potential as a therapeutic target. This antibody offers a valuable tool for studies in pharmacology, cardiovascular research, and neurobiology, contributing to advancements in the field of molecular medicine.
Product Name:
PDE1B Rabbit Polyclonal Antibody
SKU:
CAB2102
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 190-536 of human PDE1B (NP_000915.1).
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
5153
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDE1B Rabbit pAb (CAB2102) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
