The PDE12 Polyclonal Antibody (CAB17270) is a specialized tool for researchers studying phosphodiesterase 12 (PDE12), an enzyme involved in the regulation of cyclic nucleotide signaling pathways. This rabbit polyclonal antibody is highly specific for human samples and has been validated for use in Western blotting applications. By binding to the PDE12 enzyme, this antibody allows for the detection and analysis of PDE12 expression in various cell types, making it a valuable tool for studies in molecular biology and drug development.
PDE12 is known to play a key role in the degradation of cyclic nucleotides such as cAMP and cGMP, which are important second messengers in signal transduction pathways. Dysregulation of PDE12 activity has been linked to various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions. By studying the expression and function of PDE12, researchers can gain insights into its role in disease pathogenesis and potentially discover novel treatment strategies.
Product Name:
PDE12 Rabbit Polyclonal Antibody
SKU:
CAB17270
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human PDE12 (NP_001309106.1).
Enables 3'-5'-exoribonuclease activity. Involved in several processes, including RNA metabolic process; cellular response to cytokine stimulus; and regulation of mitochondrial mRNA stability. Located in mitochondrial matrix.
Purification Method:
Affinity purification
Gene ID:
201626
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDE12 Rabbit pAb (CAB17270) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
