The PDE11A Polyclonal Antibody (CAB16121) is a valuable tool for researchers studying the phosphodiesterase 11A enzyme, which plays a crucial role in regulating intracellular levels of cyclic nucleotides. This antibody, produced in rabbits, shows high reactivity with human samples and is specifically validated for use in Western blot applications.PDE11A is a member of the phosphodiesterase enzyme family that is involved in hydrolyzing cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in cells. Dysregulation of PDE11A has been linked to various diseases, including cancer, cardiovascular disorders, and neurological conditions. By targeting PDE11A with this antibody, researchers can detect and analyze the enzyme in different cell types, providing valuable insights into its function and potential therapeutic implications.
This antibody is a valuable tool for studies in molecular biology, pharmacology, and drug development, as understanding the role of PDE11A in cellular signaling pathways can lead to the development of targeted therapies for a range of diseases. Researchers can use this antibody to investigate the expression and activity of PDE11A in various experimental settings, furthering our understanding of this important enzyme and its implications in human health and disease.
Product Name:
PDE11A Rabbit Polyclonal Antibody
SKU:
CAB16121
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 712-933 of human PDE11A (NP_058649.3).
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
50940
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDE11A Rabbit pAb (CAB16121) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
