PDE11A Rabbit Polyclonal Antibody (CAB16121)
- SKU:
- CAB16121
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | PDE11A Rabbit Polyclonal Antibody |
SKU: | CAB16121 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 712-933 of human PDE11A (NP_058649.3). |
Sequence: | NNAF QAKS GSAL AQLY GTSA TLEH HHFN HAVM ILQS EGHN IFAN LSSK EYSD LMQL LKQS ILAT DLTL YFER RTEF FELV SKGE YDWN IKNH RDIF RSML MTAC DLGA VTKP WEIS RQVA ELVT SEFF EQGD RERL ELKL TPSA IFDR NRKD ELPR LQLE WIDS ICMP LYQA LVKV NVKL KPML DSVA TNRS KWEE LHQK RLLA STAS SSPA SVMV AKED RN |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | PPNAD2; PDE11A |
Positive Sample: | Mouse brain,Mouse testis,Mouse liver,Rat brain,Rat testis,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, cytosol |
Calculated MW: | 105kDa |
Observed MW: | 105kDa |
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 50940 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |