The PDE10A Polyclonal Antibody (CAB15597) is a valuable tool for researchers studying PDE10A, a phosphodiesterase enzyme that plays a role in regulating intracellular levels of cyclic nucleotides. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications.PDE10A is involved in various cellular processes, including signal transduction and neurotransmission, making it a target of interest in studies related to neurological disorders and psychiatric conditions. By binding specifically to the PDE10A protein, this antibody enables researchers to detect and analyze its expression in different cell types, providing insights into its function and potential therapeutic targeting.
The unique characteristics of PDE10A make it a promising candidate for drug development in conditions such as schizophrenia, Huntington's disease, and other neurological disorders. The PDE10A Polyclonal Antibody offers researchers a reliable tool for investigating the role of this enzyme in health and disease, opening up new possibilities for understanding and treating these complex conditions.
Product Name:
PDE10A Rabbit Polyclonal Antibody
SKU:
CAB15597
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-200 of human PDE10A (NP_001124162.1).
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
10846
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of rat brain, using PDE10A antibody (CAB15597) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
