The PDE10A Monoclonal Antibody is a vital tool for researchers studying phosphodiesterase 10A, an enzyme involved in regulating cellular signaling pathways. This monoclonal antibody, produced using hybridoma technology, is highly specific to human PDE10A and has been validated for use in various applications such as immunohistochemistry and ELISA.Phosphodiesterase 10A plays a crucial role in the central nervous system and has been implicated in various neurological disorders, including schizophrenia and Huntington's disease.
By targeting PDE10A with this monoclonal antibody, researchers can gain insights into its function and potential therapeutic implications for these conditions.With its high specificity and sensitivity, the PDE10A Monoclonal Antibody is an essential tool for researchers aiming to unravel the complexities of cellular signaling and neurological disorders. Its application in research on PDE10A makes it a valuable asset for advancing our understanding of these diseases and exploring potential treatment strategies.
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
10846
Clone Number:
ARC58635
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PDE10A antibody (CAB22757) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
