The PDCD6 Polyclonal Antibody (CAB6685) is a valuable tool for researchers studying the PDCD6 protein, a key player in apoptosis and cellular signaling pathways. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to PDCD6, this antibody enables researchers to detect and analyze the protein in various cell types, making it an ideal choice for studies in cell biology and cancer research.PDCD6, also known as programmed cell death protein 6, is involved in regulating cell death and survival processes, making it a crucial target for understanding disease mechanisms and developing therapeutic interventions.
Dysregulation of PDCD6 has been implicated in cancer progression, neurodegenerative disorders, and cardiovascular diseases, highlighting its importance in various pathological conditions. By studying the function of PDCD6, researchers can uncover potential targets for drug development and precision medicine approaches.
Product Name:
PDCD6 Rabbit Polyclonal Antibody
SKU:
CAB6685
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-191 of human PDCD6 (NP_037364.1).
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5.
Purification Method:
Affinity purification
Gene ID:
10016
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type(WT) and PDCD6 knockout (KO) 293T(KO) cells, using [KO Validated] PDCD6 Rabbit pAb (CAB6685) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
