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PDCD4 Monoclonal Antibody [Pk4C1AT] (CPAB0523)

SKU:
CPAB0523
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
Pk4C1AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

PDCD4 Monoclonal Antibody [Pk4C1AT] (CPAB0523)

The PDCD4 Polyclonal Antibody (CPAB0523) is a valuable tool for researchers studying programmed cell death protein 4 (PDCD4), a tumor suppressor protein involved in various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.PDCD4 plays a crucial role in regulating cell proliferation, differentiation, and apoptosis, making it a key player in cancer development and progression. By targeting PDCD4 with this antibody, researchers can detect and analyze the protein in different cell types, aiding in the study of cancer biology and potential therapeutic interventions.

Understanding the function and regulation of PDCD4 is essential for developing targeted therapies for cancer and other diseases. With the PDCD4 Polyclonal Antibody (CPAB0523), researchers can delve deeper into the mechanisms underlying PDCD4's role in cellular processes, offering valuable insights for the development of novel treatments.

Product Name:PDCD4 Antibody
Product Sku:CPAB0523
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PDCD4 mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PDCD4 amino acids 1-469 purified from Ecoli.
Clone:Pk4C1AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:PDCD4 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:PDCD4 is restricted to the nucleus in proliferating cells. Expression of PDCD4 is modulated by cytokines in natural killer and T cells. PDCD4 takes part in apoptosis. PDCD4 is a translation inhibitor targeted for degradation during tumor promotion. PDCD4 promotes colonic neoplastic transformation and tumor invasion. PDCD4 is an important target for microrna R-21 in breast cancer cells. Shortage of PDCD4 expression is associated with colorectal cancer. PDCD4 is swiftly phosphorylated by S6K1 kinase protein & afterwords degraded by ubiquitin ligase SCF in response to mitogens. PDCD4 in response to mitogens allows competent protein synthesis & cell growth. PDCD4 is a proapoptotic protein involved in TGF-beta1-induced apoptosis in human HCC cells, and a tumor suppressor in hepatocarcinogenesis. PDCD4 restraines tumor progression in colon carcinoma cells by the novel mechanism of down-regulating MAP4K1 transcription, with consequent inhibition of c-Jun activation and AP-1-dependent transcription.
Synonyms:Programmed cell death protein 4, Nuclear antigen H731-like, Neoplastic transformation inhibitor protein, Protein 197/15a, PDCD4, H731, MGC33046, MGC33047.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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