[KO Validated] PD-1/CD279 Polyclonal Antibody (CAB5584)
- SKU:
- CAB5584
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | [KO Validated] PD-1/CD279 Polyclonal Antibody |
SKU: | CAB5584 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 21-170 of human PD-1/CD279 (NP_005009.2). |
Sequence: | PGWF LDSP DRPW NPPT FSPA LLVV TEGD NATF TCSF SNTS ESFV LNWY RMSP SNQT DKLA AFPE DRSQ PGQD CRFR VTQL PNGR DFHM SVVR ARRN DSGT YLCG AISL APKA QIKE SLRA ELRV TERR AEVP TAHP SPSP RPAG QFQT LV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; 79 |
Positive Sample: | 293T,RAW264.7,Mouse spleen,Mouse thymus,Rat spleen,Rat thymus |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 32kDa |
Observed MW: | 35kDa |
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.
Purification Method: | Affinity purification |
Gene ID: | 5133 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |