The PDCD1 Polyclonal Antibody (CAB5584) is a powerful tool for researchers studying the programmed cell death 1 (PDCD1) protein, also known as PD-1. This cell surface receptor is a critical regulator of immune responses, particularly in the context of immune tolerance and the prevention of autoimmune diseases. Raised in rabbits, this antibody exhibits high specificity towards human samples and has been validated for Western blot applications. By binding to the PDCD1 protein, researchers can accurately detect and analyze its expression in various cell types, making it an invaluable asset for studies in immunology, oncology, and autoimmune disorders.
The PD-1 pathway has emerged as a promising target for immunotherapy in the treatment of various cancers, as well as other autoimmune and inflammatory conditions. By understanding the role of PDCD1 in immune regulation, researchers can develop novel therapies that enhance immune responses against cancer cells or dampen excessive immune reactions in autoimmune diseases. Overall, the PDCD1 Polyclonal Antibody (CAB5584) offers researchers a reliable tool to further explore the complex mechanisms of immune regulation and potentially develop new therapeutic strategies for a range of diseases.
Product Name:
[KO Validated] PD-1/CD279 Polyclonal Antibody
SKU:
CAB5584
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-170 of human PD-1/CD279 (NP_005009.2).
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.
Purification Method:
Affinity purification
Gene ID:
5133
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PD-1/CD279 antibody (CAB5584) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
