The PDCD1 Polyclonal Antibody (CAB11973) is a valuable tool for research into the programmed cell death protein 1 (PDCD1), also known as PD-1. This cell surface receptor is a key regulator of immune responses, with its primary function being to inhibit T-cell activity and prevent autoimmune reactions.Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the PDCD1 protein, it enables accurate detection and analysis, making it ideal for studies in immunology and cancer research.
The role of PDCD1 in immune regulation has garnered significant interest in the scientific community, particularly in the development of therapies for cancer and autoimmune diseases. By understanding the mechanisms by which PDCD1 inhibits immune responses, researchers can potentially exploit this knowledge to enhance anti-tumor immunity or alleviate autoimmune conditions.Overall, the PDCD1 Polyclonal Antibody is a crucial tool for investigating the function of PDCD1 in immune regulation and its implications for therapeutic interventions.
Product Name:
PD-1/CD279 Rabbit Polyclonal Antibody
SKU:
CAB11973
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 205-259 of human PD-1/CD279 (NP_005009.2).
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.
Purification Method:
Affinity purification
Gene ID:
5133
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PD-1/CD279 Rabbit pAb (CAB11973) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
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