The PD-L2/CD273/B7-DC Polyclonal Antibody is a valuable tool for research involving the PD-L2 protein, also known as CD273 or B7-DC, which plays a key role in immune regulation. This antibody, generated in rabbits, is highly specific and reactive with human samples, making it ideal for studies in immunology and cancer research.PD-L2 is a co-inhibitory molecule expressed on antigen-presenting cells and tumor cells, which interacts with its receptor PD-1 to suppress T cell activation and promote immune tolerance. Understanding the function of PD-L2 is crucial for developing immunotherapies for cancer and autoimmune diseases.
Validated for use in Western blot applications, this antibody binds specifically to the PD-L2 protein, allowing for accurate detection and analysis in various cell types. Its high specificity and sensitivity make it a reliable tool for studying the expression and regulation of PD-L2 in different physiological and pathological conditions.Overall, the PD-L2/CD273/B7-DC Polyclonal Antibody is a valuable resource for researchers investigating the role of PD-L2 in immune regulation and its potential as a therapeutic target in various diseases.
Acts upstream of or within negative regulation of T cell proliferation and positive regulation of T cell proliferation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system epithelium; forebrain; nose; retina; and skin. Orthologous to human PDCD1LG2 (programmed cell death 1 ligand 2).
Purification Method:
Affinity purification
Gene ID:
58205
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Rat spleen, using PD-L2/CD273/B7-DC antibody (CAB23045) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
