PD-L1/CD274 Mouse Monoclonal Antibody (CAB18103)
- SKU:
- CAB18103
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG
- Research Area:
- Immunology
Description
Product Name: | PD-L1/CD274 Mouse Monoclonal Antibody |
SKU: | CAB18103 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant protein of human PD‐L1 extracellular domain. |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 |
Synonyms: | B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1; PD-L1/CD274 |
Positive Sample: | Raji cells,A-549 cells |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Endomembrane system, Single-pass type I membrane protein |
Calculated MW: | 33kDa |
Observed MW: | 40-50kDa |
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 29126 |
Clone Number: | ARC5110-01 |
Storage Buffer: | Store at 4℃. Avoid freeze / thaw cycles.Tris Buffer, pH7.3-7.7, with 1% BSA and <0.1% Sodium azide. |