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PD-1/CD279 Polyclonal Antibody (CAB21534)

SKU:
CAB21534
$155
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Description

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Product Name:PD-1/CD279 Polyclonal Antibody
SKU:CAB21534
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PD-1/CD279 (NP_005009.2).
Sequence:MQIP QAPW PVVW AVLQ LGWR PGWF LDSP DRPW NPPT FSPA LLVV TEGD NATF TCSF SNTS ESFV LNWY RMSP SNQT DKLA AFPE DRSQ PGQD CRFR VTQL
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; PD-1/CD279
Positive Sample:Raji
Conjugate:Unconjugated
Cellular Localization:Membrane, Single-pass type I membrane protein.
Calculated MW:32kDa
Observed MW:52-65kDa

Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.

Purification Method:Affinity purification
Gene ID:5133
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from Raji cells using PD-1/CD279 Rabbit pAb(CAB21534) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.

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