The PD-1 (CD279) Polyclonal Antibody (CAB21534) is a powerful tool for researchers studying immune regulation and immune checkpoint pathways. Specifically targeting the PD-1 protein, this antibody is raised in rabbits and is highly reactive with human samples, making it an ideal choice for Western blot applications.PD-1, also known as programmed cell death protein 1, is a key regulator of T cell function and is involved in preventing autoimmunity by inhibiting the immune response. Its role in immune checkpoint pathways has made it a significant target for cancer research, with PD-1 inhibitors showing promise in immunotherapy treatments.
This antibody enables precise detection and analysis of PD-1 expression, allowing for in-depth studies in immunology, oncology, and beyond.By utilizing the PD-1 Polyclonal Antibody, researchers can uncover new insights into immune regulation and develop innovative therapies for diseases such as cancer, autoimmune disorders, and infectious diseases. Its high specificity and sensitivity make it a valuable asset for any research project aimed at understanding the complex mechanisms of immune system modulation.
Product Name:
PD-1/CD279 Polyclonal Antibody
SKU:
CAB21534
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PD-1/CD279 (NP_005009.2).
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity.
Purification Method:
Affinity purification
Gene ID:
5133
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Raji cells using PD-1/CD279 Rabbit pAb(CAB21534) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
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