Proprotein Convertase 9(PCSK9) Rabbit Monoclonal Antibody (CAB11532)
- SKU:
- CAB11532
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | Proprotein Convertase 9(PCSK9) Rabbit Monoclonal Antibody |
SKU: | CAB11532 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 593-692 of human Proprotein Convertase 9(PCSK9) (NP_777596.2). |
Sequence: | EASI HASC CHAP GLEC KVKE HGIP APQE QVTV ACEE GWTL TGCS ALPG TSHV LGAY AVDN TCVV RSRD VSTT GSTS EGAV TAVA ICCR SRHL AQAS QELQ |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3; [KD Validated] Proprotein Convertase 9(PCSK9) |
Positive Sample: | HeLa,HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell surface, Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Secreted. |
Calculated MW: | 74kDa |
Observed MW: | 65kDa/80kDa |
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 255738 |
Clone Number: | ARC50558 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |