Proprotein Convertase 9(PCSK9) Rabbit Polyclonal Antibody (CAB7860)
- SKU:
- CAB7860
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | Proprotein Convertase 9(PCSK9) Rabbit Polyclonal Antibody |
SKU: | CAB7860 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 590-692 of human Proprotein Convertase 9(PCSK9) (NP_777596.2). |
Sequence: | GHRE ASIH ASCC HAPG LECK VKEH GIPA PQEQ VTVA CEEG WTLT GCSA LPGT SHVL GAYA VDNT CVVR SRDV STTG STSE GAVT AVAI CCRS RHLA QASQ ELQ |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3; Proprotein Convertase 9(PCSK9) |
Positive Sample: | HeLa,Mouse liver,Rat liver,Rat testis,HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cell surface, Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Secreted. |
Calculated MW: | 74kDa |
Observed MW: | 80kDa/65kDa, |
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 255738 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |