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PCSK7 Antibody (PACO11115)

SKU:
PACO11115
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$551

Description

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PCSK7 Antibody (PACO11115)

The PCSK7 Polyclonal Antibody (PACO11115) is an essential tool for researchers studying PCSK7, a member of the proprotein convertase family involved in the processing of secretory proteins. This high-quality antibody, produced in rabbits, exhibits strong reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the PCSK7 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a valuable asset for studies in biochemistry and molecular biology.

PCSK7 plays a crucial role in regulating protein maturation and secretion, making it a key player in various cellular processes. Its involvement in protein processing pathways makes PCSK7 an intriguing target for research into diseases such as diabetes, obesity, and cardiovascular disorders. Understanding the function of PCSK7 is essential for unraveling the complexities of these conditions and developing targeted therapies to address them.

Antibody Name:PCSK7 Antibody (PACO11115)
Antibody SKU:PACO11115
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human PCSK7
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:proprotein convertase subtilisin/kexin type 7;PCSK7;LPC;PC7;PC8;SPC7 ;
UniProt Protein Function:PCSK7: Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif. Belongs to the peptidase S8 family.Protein type: Protease; Membrane protein, integral; EC 3.4.21.-Chromosomal Location of Human Ortholog: 11q23-q24Cellular Component: integral to Golgi membraneMolecular Function: peptidase activity; serine-type endopeptidase activityBiological Process: protein processing
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes and plays a role in the regulation of iron metabolism. A t(11;14)(q23;q32) chromosome translocation associated with B-cell lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq, Feb 2014]
UniProt Code:Q16549
NCBI GenInfo Identifier:205830663
NCBI Gene ID:9159
NCBI Accession:Q16549.2
UniProt Secondary Accession:Q16549,Q3C1X1, Q53GM4, Q96FK8, Q9UL57, B0YJ60
UniProt Related Accession:Q16549
Molecular Weight:86,247 Da
NCBI Full Name:Proprotein convertase subtilisin/kexin type 7
NCBI Synonym Full Names:proprotein convertase subtilisin/kexin type 7
NCBI Official Symbol:PCSK7  
NCBI Official Synonym Symbols:LPC; PC7; PC8; SPC7  
NCBI Protein Information:proprotein convertase subtilisin/kexin type 7
UniProt Protein Name:Proprotein convertase subtilisin/kexin type 7
UniProt Synonym Protein Names:Lymphoma proprotein convertase; Prohormone convertase 7; Proprotein convertase 7; PC7; Proprotein convertase 8; PC8; hPC8; Subtilisin/kexin-like protease PC7
Protein Family:Proprotein convertase subtilisin/kexin
UniProt Gene Name:PCSK7  
UniProt Entry Name:PCSK7_HUMAN

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