PCSK5 Rabbit Polyclonal Antibody (CAB5450)
- SKU:
- CAB5450
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
Product Name: | PCSK5 Rabbit Polyclonal Antibody |
SKU: | CAB5450 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 601-913 of human PCSK5 (NP_006191.2). |
Sequence: | QPYS PTNE FPKV ERFR YSRV EDPT DDYG TEDY AGPC DPEC SEVG CDGP GPDH CNDC LHYY YKLK NNTR ICVS SCPP GHYH ADKK RCRK CAPN CESC FGSH GDQC MSCK YGYF LNEE TNSC VTHC PDGS YQDT KKNL CRKC SENC KTCT EFHN CTEC RDGL SLQG SRCS VSCE DGRY FNGQ DCQP CHRF CATC AGAG ADGC INCT EGYF MEDG RCVQ SCSI SYYF DHSS ENGY KSCK KCDI SCLT CNGP GFKN CTSC PSGY LLDL GMCQ MGAI CKDA TEES WAEG GFCM LVKK NNLC QRKV LQQL CCKT CTFQ G |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | PC5; PC6; PC6A; SPC6; PCSK5 |
Positive Sample: | Jurkat,SW480,Mouse lung,Rat lung,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Endomembrane system, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 207kDa |
Observed MW: | 102kDa |
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B).
Purification Method: | Affinity purification |
Gene ID: | 5125 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |