PCSK1 Rabbit Polyclonal Antibody (CAB12237)
- SKU:
- CAB12237
- Product Type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PCSK1 Rabbit Polyclonal Antibody |
SKU: | CAB12237 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-170 of human PCSK1 (NP_000430.3). |
Sequence: | KRQF VNEW AAEI PGGP EAAS AIAE ELGY DLLG QIGS LENH YLFK HKNH PRRS RRSA FHIT KRLS DDDR VIWA EQQY EKER SKRS ALRD SALN LFND PMWN QQWY LQDT RMTA ALPK LDLH VIPV WQKG ITGK GVVI TVLD DGL |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | PC1; PC3; NEC1; SPC3; PC1/3; BMIQ12; PCSK1 |
Positive Sample: | Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasmic vesicle, secretory vesicle. |
Calculated MW: | 84kDa |
Observed MW: | 84kDa |
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene
Purification Method: | Affinity purification |
Gene ID: | 5122 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |