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PCNA Monoclonal Antibody (MACO0656)

SKU:
MACO0656
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
ELISA
Conjugation:
Unconjugated
Isotype:
IgG1
Host Species:
Mouse
€249
Frequently bought together:

Description

PCNA Monoclonal Antibody (MACO0656)

The PCNA Monoclonal Antibody (MACO0656) is a valuable tool for researchers studying PCNA, a protein essential for DNA replication and repair. This antibody, produced using monoclonal technology, is highly specific for PCNA and is validated for use in various applications, including Western blotting and immunofluorescence.PCNA, also known as proliferating cell nuclear antigen, is a key player in maintaining genomic stability and ensuring accurate DNA replication. Dysregulation of PCNA has been implicated in various diseases, including cancer and neurodegenerative disorders.

By targeting PCNA with this monoclonal antibody, researchers can better understand its role in these conditions and potentially develop targeted therapies.With its high specificity and reliability in detecting PCNA expression, the MACO0656 antibody is a valuable tool for advancing research in the fields of cancer biology, genomics, and cell cycle regulation. Its ability to accurately detect PCNA in different cell types makes it a versatile asset for scientists seeking to unravel the complexities of DNA replication and repair mechanisms.

Product Name:PCNA Monoclonal Antibody
Product Code:MACO0656
Size: 50µg
Target Names:PCNA
Species Reactivity:N/A
Host Species:Mouse
Antigen Species:N/A
Tested Applications:ELISA
Isotype:IgG1
Clone ID:N/A
Conjugate:Non-conjugated
Clonality:Monoclonal
Antigen:PCNA fusion protein
Form:Liquid
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:Protein G purified
Storage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Aliases:Cyclin, PCNA
Uniprot ID:N/A
Background:Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase δ in eukaryotic cells. This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. PCNA induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. It has to be loaded onto DNA in order to be able to stimulate APEX2. PCNA protein is highly conserved during evolution; the deduced amino acid sequences of rat and human differ by only 4 of 261 amino acids. PCNA has been used as loading control for proliferating cells. This antibody is a rabbit polyclonal antibody raised against an internal region of human PCNA.
Research Area:Others

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