The PCNA Monoclonal Antibody (AGEL3801) is a valuable tool for researchers studying PCNA, a protein essential for DNA replication and repair processes. This antibody, derived from mouse hybridoma cells, specifically targets PCNA and is highly reactive in human samples, making it a reliable choice for Western blot and immunohistochemistry applications.PCNA, also known as proliferating cell nuclear antigen, plays a crucial role in maintaining genomic stability and cell cycle progression. Its overexpression is often associated with cancer development and progression, making it a potential target for cancer therapy research.
The PCNA Monoclonal Antibody aids in the detection and analysis of PCNA levels in various cell types, providing valuable insights into its function and potential implications in cancer biology.With its high specificity and sensitivity, the PCNA Monoclonal Antibody (AGEL3801) is a versatile tool for researchers investigating DNA replication, repair mechanisms, and the role of PCNA in cancer biology. Its reliability and consistent performance make it a valuable asset in advancing our understanding of cellular processes and potential therapeutic targets in oncology.
PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Calculated MW:
29kDa
Observed MW:
29kDa
Background:
This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2.
Purification Method:
Protein A purification
Cellular Localization:
Nucleus
Storage:
Store at -20℃. Avoid freeze / thaw cycles.
Swissprot:
P12004
Research Areas:
Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Tags and Cell Markers
