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PCNA Monoclonal Antibody [Pk1A3AT] (CPAB0525)

SKU:
CPAB0525
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG3
Clone:
Pk1A3AT
Applications:
WB
ELISA
$179
Frequently bought together:

Description

system_update_alt Datasheet

PCNA Monoclonal Antibody [Pk1A3AT] (CPAB0525)

The PCNA Polyclonal Antibody (CPAB0525) is a valuable tool for researchers studying PCNA, a protein involved in DNA replication and repair processes. This antibody, generated in rabbits, exhibits high specificity for detecting PCNA in human samples and has been validated for use in Western blot applications. By binding to PCNA, the antibody allows for precise detection and analysis of this important protein in a variety of cell types, making it ideal for research in fields such as molecular biology, oncology, and genetics.PCNA, also known as proliferating cell nuclear antigen, plays a crucial role in maintaining genomic stability and ensuring accurate DNA replication.

Dysregulation of PCNA has been implicated in various diseases, including cancer and genetic disorders. By studying the expression and activity of PCNA, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.Overall, the PCNA Polyclonal Antibody (CPAB0525) is a reliable reagent for investigating the function and regulation of PCNA in biological processes, providing researchers with a valuable tool for advancing their understanding of DNA replication and repair pathways.

Product Name:PCNA Antibody
Product Sku:CPAB0525
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PCNA mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PCNA amino acids 1-261 purified from Ecoli.
Clone:Pk1A3AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:PCNA antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG3
Background:PCNA is located in the nucleus and is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps elevate the processivity of leading strand synthesis during DNA replication. In reaction to DNA damage, PCNA is ubiquitinated and takes part in the RAD6-dependent DNA repair pathway. 2 transcript variants encoding the same protein have been found for PCNA gene. Pseudogenes of this PCNA gene have been described on chromosome 4 and on the X chromosome. PCNA is expressed during late G1- phase, S-phase of mitosis and persists until the end of the M-phase because of its long biological half-life. PCNA is induced by UV irradiation.
Synonyms:Proliferating cell nuclear antigen, PCNA, Cyclin, MGC8367.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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