The PCMT1 Polyclonal Antibody (CAB6684) is a valuable tool for researchers studying the PCMT1 protein, an essential enzyme involved in protein post-translational modification. This antibody, produced in rabbits, demonstrates high specificity and sensitivity when detecting PCMT1 in human samples, making it ideal for Western blot applications.PCMT1 plays a crucial role in methylating protein substrates, thereby regulating their stability, localization, and function within the cell. Dysregulation of PCMT1 activity has been linked to various diseases, including neurodegenerative disorders and cancer.
By utilizing the PCMT1 Polyclonal Antibody, researchers can investigate the expression and function of PCMT1 in different cell types, advancing our understanding of its roles in health and disease.With its proven performance in Western blotting and its relevance to multiple fields of research, the PCMT1 Polyclonal Antibody (CAB6684) is a valuable tool for studies in biochemistry, cell biology, and disease mechanisms.
Product Name:
PCMT1 Rabbit Polyclonal Antibody
SKU:
CAB6684
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 62-286 of human PCMT1 (NP_001238978.1).
This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimer's disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
5110
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PCMT1 Rabbit pAb (CAB6684).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
