The PCM1 Polyclonal Antibody (CAB16637) is a valuable tool for researchers studying the PCM1 protein, a key player in centriole and cilia formation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications.PCM1 is essential for the proper assembly and function of centrioles, which are critical for cell division and cilia formation. Dysregulation of PCM1 has been linked to various diseases, including ciliopathies and cancer. By using the PCM1 Polyclonal Antibody, researchers can accurately detect and analyze PCM1 expression in various cell types, providing valuable insights into centriole dynamics and cilia-related processes.
The PCM1 Polyclonal Antibody is an indispensable tool for researchers interested in exploring the role of PCM1 in cellular organization, ciliogenesis, and disease development. Its high specificity and sensitivity make it an ideal choice for studies in cell biology, developmental biology, and cancer research. By understanding the function of PCM1, researchers can potentially uncover new therapeutic targets for diseases associated with centriole and cilia dysfunction.
Product Name:
PCM1 Rabbit Polyclonal Antibody
SKU:
CAB16637
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PCM1 (NP_006188.4).
The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5108
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Mouse brain, using PCM1 Rabbit pAb (CAB16637) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
