PCM1 Rabbit Polyclonal Antibody (CAB16637)
- SKU:
- CAB16637
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | PCM1 Rabbit Polyclonal Antibody |
SKU: | CAB16637 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PCM1 (NP_006188.4). |
Sequence: | MATG GGPF EDGM NDQD LPNW SNEN VDDR LNNM DWGA QQKK ANRS SEKN KKKF GVES DKRV TNDI SPES SPGV GRRR TKTP HTFP HSRY MSQM SVPE QAEL EKLK QRIN FSDL DQRS IGSD SQGR ATAA NNKR QLSE NRKP FNFL PMQI NTNK SKDA STNP PNRE TIGS AQCK ELFA SALS NDLL QNCQ VSEE DGRG EPAM ESSQ IVSR LVQI RDYI TKAS SMRE DLVE KNER SANV ERLT HLID HLKE QEKS YMKF LKKI |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IF/ICC,1:50 - 1:200 |
Synonyms: | PTC4; RET/PCM-1; PCM1 |
Positive Sample: | Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytoplasmic granule, centriolar satellite, centrosome, cilium basal body, cytoskeleton, microtubule organizing center. |
Calculated MW: | 229kDa |
Observed MW: | 270kDa |
The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5108 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |