PCK1 Rabbit Polyclonal Antibody (CAB2036)
- SKU:
- CAB2036
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | PCK1 Rabbit Polyclonal Antibody |
SKU: | CAB2036 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 490-622 of human PCK1 (NP_002582.3). |
Sequence: | FGKY LAHW LSMA QHPA AKLP KIFH VNWF RKDK EGKF LWPG FGEN SRVL EWMF NRID GKAS TKLT PIGY IPKE DALN LKGL GHIN MMEL FSIS KEFW EKEV EDIE KYLE DQVN ADLP CEIE REIL ALKQ RISQ M |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 400μg-600μg extracts of whole cells |
Synonyms: | PCKDC; PEPCK1; PEPCKC; PEPCK-C; PCK1 |
Positive Sample: | HepG2,Mouse liver,Mouse kidney,Rat liver,Rat pancreas,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 69kDa |
Observed MW: | 69kDa |
This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been characterized.
Purification Method: | Affinity purification |
Gene ID: | 5105 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |