The PCIF1 Polyclonal Antibody (CAB18347) is a valuable tool for researchers studying the PCIF1 protein, a factor involved in RNA processing and gene regulation. This antibody is raised in rabbits and is highly specific for detecting PCIF1 in human samples, making it ideal for Western blot applications.PCIF1, also known as mRNA polyadenylation factor PCF11, plays a crucial role in mRNA 3' end processing and polyadenylation, which are essential steps in gene expression. Dysregulation of PCIF1 has been linked to various diseases, including cancer and neurodevelopmental disorders.
Therefore, understanding the function and regulation of PCIF1 is important for unraveling its role in disease pathology.By utilizing the PCIF1 Polyclonal Antibody, researchers can study the expression and localization of PCIF1 in different cell types and tissues, providing insights into its biological functions. This antibody is a valuable tool for investigating the molecular mechanisms underlying mRNA processing and identifying potential therapeutic targets for diseases associated with PCIF1 dysregulation.
Product Name:
PCIF1 Rabbit Polyclonal Antibody
SKU:
CAB18347
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PCIF1 (NP_071387.1).
Enables RNA polymerase II C-terminal domain phosphoserine binding activity; S-adenosyl-L-methionine binding activity; and mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA methylation; negative regulation of translation; and positive regulation of translation. Located in intercellular bridge; microtubule cytoskeleton; and nucleoplasm.
Purification Method:
Affinity purification
Gene ID:
63935
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using PCIF1 Rabbit pAb (CAB18347) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
