The PCGF2 Polyclonal Antibody (CAB17327) is a crucial tool for researchers studying the PCGF2 protein, a key player in gene regulation and chromatin organization. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the PCGF2 protein, this antibody enables the detection and analysis of PCGF2 in various cell types, making it an essential component for studies in molecular biology and epigenetics.
PCGF2, also known as polycomb group ring finger protein 2, is involved in the regulation of gene expression and the maintenance of cellular identity. Its role in chromatin remodeling and transcriptional repression makes it a significant target for research in fields such as cancer biology, development, and stem cell research. Understanding the function of PCGF2 is essential for uncovering its potential implications in disease and discovering new therapeutic strategies.
Product Name:
PCGF2 Rabbit Polyclonal Antibody
SKU:
CAB17327
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 115-241 of human PCGF2 (NP_009075.1).
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses.
Purification Method:
Affinity purification
Gene ID:
7703
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat kidney, using PCGF2 antibody (CAB17327) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
