The PCDHGB3 Polyclonal Antibody (PACO11102) is a valuable tool for researchers studying the PCDHGB3 protein, an important member of the protocadherin gamma gene cluster. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.PCDHGB3 is known to play a role in cell-cell adhesion and communication, making it a key player in processes such as neuronal development and synaptic connectivity. By targeting the PCDHGB3 protein, researchers can gain insights into its functions and mechanisms of action in various cell types.
This antibody is particularly useful for studies in neuroscience, developmental biology, and cancer research, where understanding the role of cell adhesion molecules like PCDHGB3 is crucial. With its high reactivity and specificity, the PCDHGB3 Polyclonal Antibody (PACO11102) is a reliable tool for researchers looking to unravel the complexities of cell communication and signaling pathways involving the PCDHGB3 protein.
PCDHGB3: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 5q31Cellular Component: integral to membrane; plasma membraneMolecular Function: calcium ion bindingBiological Process: homophilic cell adhesion
UniProt Protein Details:
NCBI Summary:
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
