PCDHB7 Antibody (PACO64447)
- SKU:
- PACO64447
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PCDHB7 Antibody (PACO64447)
The PCDHB7 Polyclonal Antibody (PAC06447) is an essential tool for researchers studying PCDHB7, a cell surface molecule with implications in neural development and cell recognition. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the PCDHB7 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for studies in neuroscience and developmental biology.PCDHB7, a member of the protocadherin beta cluster, is known to play a crucial role in neural circuit formation and synapse plasticity.
Its involvement in cell adhesion and recognition processes makes it a key player in neurodevelopmental disorders and neurological diseases. Research on PCDHB7 can provide valuable insights into the mechanisms underlying brain development and function, with potential implications for the diagnosis and treatment of various neurological conditions. Understanding the functions of PCDHB7 is essential for advancing our knowledge of neural connectivity and signaling pathways in both health and disease.
| Antibody Name: | PCDHB7 Antibody (PACO64447) |
| Antibody SKU: | PACO64447 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | IHC:1:100-1:500, IF:1:100-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protocadherin beta-7 protein (463-682AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO64447 diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. |
 | Immunofluorescence staining of U87 cells with PACO64447 at 1:500, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | IHC image of PACO64447 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. |
| Background: | Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. |
| Synonyms: | Protocadherin beta-7 (PCDH-beta-7), PCDHB7 |
| UniProt Protein Function: | Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.Subcellular location: Cell membrane; Single-pass type I membrane protein By similarity. Sequence similarities: Contains 6 cadherin domains. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. The transcript for this particular family member uses more than one polyadenylation site. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5E2 |
| NCBI GenInfo Identifier: | 11036656 |
| NCBI Gene ID: | 56129 |
| NCBI Accession: | NP_061763.1 |
| UniProt Secondary Accession: | Q9Y5E2,A1L3Y8 |
| UniProt Related Accession: | Q9Y5E2 |
| Molecular Weight: | 86,707 Da |
| NCBI Full Name: | protocadherin beta-7 |
| NCBI Synonym Full Names: | protocadherin beta 7 |
| NCBI Official Symbol: | PCDHB7Â Â |
| NCBI Official Synonym Symbols: | PCDH-BETA7Â Â |
| NCBI Protein Information: | protocadherin beta-7 |
| UniProt Protein Name: | Protocadherin beta-7 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Protocadherin |
| UniProt Gene Name: | PCDHB7Â Â |
| UniProt Entry Name: | PCDB7_HUMAN |
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