PCDHB15 Antibody (PACO20192)
- SKU:
- PACO20192
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PCDHB15 Antibody (PACO20192)
The PCDHB15 Polyclonal Antibody (PAC020192) is a crucial tool for research involving PCDHB15, a member of the protocadherin beta cluster of proteins that are involved in cell-cell adhesion and communication. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the PCDHB15 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for studies in developmental biology and neurobiology.PCDHB15, a cell adhesion molecule, plays a key role in neuronal development and connectivity by mediating cell-cell interactions in the nervous system.
Its involvement in these processes highlights its importance in understanding neural circuit formation and function. Research into PCDHB15 is essential for unraveling the mechanisms underlying neural development and synaptic plasticity, with potential implications for neurological disorders and neurodegenerative diseases. Gain insights into the functions of PCDHB15 with the use of this reliable and specific polyclonal antibody.
| Antibody Name: | PCDHB15 Antibody (PACO20192) |
| Antibody SKU: | PACO20192 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human PCDHB15 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20192(PCDHB15 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20192(PCDHB15 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene is a member of the protocadherin β gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The β cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. |
| Synonyms: | protocadherin β 15 |
| UniProt Protein Function: | PCDHB15: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 5q31Cellular Component: integral to plasma membraneMolecular Function: calcium ion bindingBiological Process: nervous system development; cell adhesion; homophilic cell adhesion |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5E8 |
| NCBI GenInfo Identifier: | 13431379 |
| NCBI Gene ID: | 56121 |
| NCBI Accession: | Q9Y5E8.1 |
| UniProt Secondary Accession: | Q9Y5E8,Q8IUX5 |
| UniProt Related Accession: | Q9Y5E8 |
| Molecular Weight: | 86,329 Da |
| NCBI Full Name: | Protocadherin beta-15 |
| NCBI Synonym Full Names: | protocadherin beta 15 |
| NCBI Official Symbol: | PCDHB15Â Â |
| NCBI Official Synonym Symbols: | PCDH-BETA15Â Â |
| NCBI Protein Information: | protocadherin beta-15 |
| UniProt Protein Name: | Protocadherin beta-15 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Protocadherin |
| UniProt Gene Name: | PCDHB15Â Â |
| UniProt Entry Name: | PCDBF_HUMAN |
| Antibodies |
| PCDHB15 Antibody (PACO11100) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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