The PCDHB15 Polyclonal Antibody (PAC011100) is a valuable tool for researchers studying PCDHB15, a protein belonging to the protocadherin beta family involved in cell-cell adhesion and signaling. This antibody, generated in rabbits, exhibits high specificity towards human samples and is optimized for Western blot applications. It recognizes the PCDHB15 protein, allowing for precise detection and analysis in various cell types, making it suitable for investigations in developmental biology, neuroscience, and cancer research.PCDHB15, a member of the PCDH gene cluster, is known to play a role in neuronal wiring and synapse formation, making it a key player in nervous system development and function.
Its involvement in cell adhesion and signaling processes makes it a promising target for understanding neurological disorders, such as autism and schizophrenia, where synaptic connectivity abnormalities have been observed. By elucidating the functions of PCDHB15, researchers can uncover potential therapeutic strategies for treating these conditions and advancing our knowledge of neural circuitry.
PCDHB15: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 5q31Cellular Component: integral to plasma membraneMolecular Function: calcium ion bindingBiological Process: nervous system development; cell adhesion; homophilic cell adhesion
UniProt Protein Details:
NCBI Summary:
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]
