The PCDHB12 Polyclonal Antibody (PACO11099) is a valuable tool for researchers studying PCDHB12, a cell adhesion molecule known to play a role in neuronal development and connectivity. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications including Western blotting. By specifically binding to the PCDHB12 protein, this antibody enables the detection and analysis of PCDHB12 in different cell types, making it ideal for investigations in neurobiology and developmental biology.
PCDHB12, a member of the protocadherin family, is essential for the establishment of proper neuronal connections in the brain. Its involvement in mediating cell-cell interactions suggests its potential significance in neurological disorders and synaptic plasticity. Researchers studying brain development, neurodegenerative diseases, and cognitive function can benefit from using this antibody to further explore the functions and mechanisms of PCDHB12 in neuronal processes.
PCDHB12: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.Protein type: Membrane protein, integral; Cell adhesionChromosomal Location of Human Ortholog: 5q31Cellular Component: integral to plasma membraneBiological Process: cell adhesion; nervous system development
UniProt Protein Details:
NCBI Summary:
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]
