The PCDHB11 Polyclonal Antibody (PACO20190) is a valuable tool for researchers studying the PCDHB11 protein, a member of the protocadherin beta cluster involved in cell adhesion and neuronal development. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications.PCDHB11 is known to play a role in neuronal connectivity and synaptic plasticity, making it a key player in brain development and function. By targeting the PCDHB11 protein, researchers can gain insights into the mechanisms underlying neural circuit formation and function, as well as its potential implications for neurological disorders.
The PCDHB11 Polyclonal Antibody is a versatile tool for studying PCDHB11 expression and localization in various cell types and tissues, making it ideal for neuroscience research focused on understanding the intricate processes of brain development and function. Its application extends to studies investigating neurodevelopmental disorders, neuronal connectivity, and synaptic plasticity, providing valuable insights into the complexities of the brain.
Antibody Name:
PCDHB11 Antibody (PACO20190)
Antibody SKU:
PACO20190
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human PCDHB11
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20190(PCDHB11 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is a member of the protocadherin β gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The β cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections.
Synonyms:
protocadherin β 11
UniProt Protein Function:
PCDHB11: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.Protein type: Cell adhesion; Membrane protein, integralChromosomal Location of Human Ortholog: 5q31Cellular Component: integral to plasma membraneBiological Process: cell adhesion; nervous system development; synaptic transmission; synaptogenesis
UniProt Protein Details:
NCBI Summary:
This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq, Jul 2008]
