The PCDHAC2 Polyclonal Antibody (PAC020186) is a valuable tool for researchers studying PCDHAC2, a cell adhesion molecule that plays a key role in cell-cell recognition and communication. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding to the PCDHAC2 protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for studies in cell biology and developmental biology.PCDHAC2 is involved in mediating cell adhesion and signaling processes, impacting various cellular functions such as cell migration, differentiation, and tissue development.
Its importance in cell communication makes it a promising target for research in fields like neuroscience, developmental biology, and cancer biology. Understanding the function of PCDHAC2 is essential for uncovering its potential role in disease processes and developing targeted therapies for related disorders.Overall, the PCDHAC2 Polyclonal Antibody (PAC020186) offers researchers a reliable tool for investigating the complex functions of PCDHAC2 in various biological processes, providing valuable insights into cell-to-cell interactions and their implications in health and disease.
Antibody Name:
PCDHAC2 Antibody (PACO20186)
Antibody SKU:
PACO20186
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human PCDHAC2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO20186(PCDHAC2 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is a member of the protocadherin α gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The α gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences.
Synonyms:
protocadherin α subfamily C, 2
UniProt Protein Function:
PCDHAC2: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 5q31Cellular Component: integral to plasma membraneBiological Process: cell adhesion
UniProt Protein Details:
NCBI Summary:
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
