PCDHAC1 Antibody (PACO20185)
- SKU:
- PACO20185
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
PCDHAC1 Antibody (PACO20185)
The PCDHAC1 Polyclonal Antibody (PACO20185) is a valuable tool for researchers studying PCDHAC1, a cell adhesion molecule with implications in various biological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the PCDHAC1 protein, this antibody enables the detection and analysis of PCDHAC1 in different cell types, making it an ideal choice for studies in cell adhesion and developmental biology.PCDHAC1 is known for its role in cell adhesion and tissue development, making it a critical player in processes like cell migration and organogenesis.
Its involvement in these fundamental biological processes highlights its importance as a target for research in developmental biology, cancer metastasis, and neurological disorders. Investigating the mechanisms of PCDHAC1 can provide valuable insights into cell adhesion dynamics and may uncover potential therapeutic strategies for diseases related to aberrant cell adhesion.
| Antibody Name: | PCDHAC1 Antibody (PACO20185) |
| Antibody SKU: | PACO20185 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human PCDHAC1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20185(PCDHAC1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane: A549 cells, Primary antibody: PACO20185(PCDHAC1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO20185(PCDHAC1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene is a member of the protocadherin α gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The α gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. |
| Synonyms: | protocadherin α subfamily C, 1 |
| UniProt Protein Function: | PCDHAC1: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 5q31Cellular Component: integral to plasma membraneMolecular Function: calcium ion bindingBiological Process: nervous system development; cell adhesion; homophilic cell adhesion |
| UniProt Protein Details: | |
| NCBI Summary: | This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H158 |
| NCBI GenInfo Identifier: | 143811434 |
| NCBI Gene ID: | 56135 |
| NCBI Accession: | Q9H158.2 |
| UniProt Secondary Accession: | Q9H158,Q9Y5F5, Q9Y5I5 |
| UniProt Related Accession: | Q9H158 |
| Molecular Weight: | |
| NCBI Full Name: | Protocadherin alpha-C1 |
| NCBI Synonym Full Names: | protocadherin alpha subfamily C, 1 |
| NCBI Official Symbol: | PCDHAC1Â Â |
| NCBI Official Synonym Symbols: | PCDH-ALPHA-C1Â Â |
| NCBI Protein Information: | protocadherin alpha-C1 |
| UniProt Protein Name: | Protocadherin alpha-C1 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Protocadherin |
| UniProt Gene Name: | PCDHAC1Â Â |
| UniProt Entry Name: | PCDC1_HUMAN |
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